Miralem Pjanic is a doubt for the home side after missing their last three matches through injury. Sami Khedira is back in contention for the home side to provide other midfield options for Max Allegri, but Claudio Marchisio hasn't featured since August and remains a doubt.
Paulo Dybala was given a rest at the weekend and that decision backfired as he came off the bench to miss a stoppage time penalty that would have secured a point at home to Lazio. He will at least be fresh to start here.
Bas Dost should start his first Champions League group stage match of the campaign with Doumbia expected to miss out, while Jonathan Silva is ready to deputise in Coentrão's absence.
No other changes are expected from the away side.